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Background:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B.
Applications:
WB, IHC
Name of antibody:
MAP3K7(Ab-187)
Immunogen:
Synthesized non-phosphopeptide derived from human MAP3K7 around the phosphorylation site of threonine 187 (H-M-T(p)-N-N).
Full name:
mitogen-activated protein kinase kinase kinase 7
Synonyms:
TAK1; MEKK7; TGF1a
SwissProt:
O43318
IHC positive control:
Human breast carcinoma tissue
IHC Recommend dilution:
50-100
WB Predicted band size:
67 kDa
WB Positive control:
Jurkat cells treated with heat shock lysate
WB Recommended dilution:
500-3000